Title : Chemical modifications of the protein of carcinoembryonic antigen: associated changes in immunological activity and conformation.

Pub. Date : 1978 Feb

PMID : 629857






7 Functional Relationships(s)
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Protein Name
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1 Chemical substitution of the exposed residues of tryptophan, tyrosine, histidine and arginine in carcinoembryonic antigen (CEA), using appropriately selective reagents, caused no significant change in the capacity of the antigen to bind to anti-CEA serum. Tryptophan CEA cell adhesion molecule 3 Homo sapiens
2 Chemical substitution of the exposed residues of tryptophan, tyrosine, histidine and arginine in carcinoembryonic antigen (CEA), using appropriately selective reagents, caused no significant change in the capacity of the antigen to bind to anti-CEA serum. Arginine CEA cell adhesion molecule 3 Homo sapiens
3 Chemical substitution of the exposed residues of tryptophan, tyrosine, histidine and arginine in carcinoembryonic antigen (CEA), using appropriately selective reagents, caused no significant change in the capacity of the antigen to bind to anti-CEA serum. Arginine CEA cell adhesion molecule 3 Homo sapiens
4 However, treatments of CEA with 2-hydroxy-5-nitrobenzyl bromide and tetranitromethane, both in the presence of guanidine HCl, caused a large reduction in binding capacity. 2-Hydroxy-5-nitrobenzyl Bromide CEA cell adhesion molecule 3 Homo sapiens
5 However, treatments of CEA with 2-hydroxy-5-nitrobenzyl bromide and tetranitromethane, both in the presence of guanidine HCl, caused a large reduction in binding capacity. Tetranitromethane CEA cell adhesion molecule 3 Homo sapiens
6 However, treatments of CEA with 2-hydroxy-5-nitrobenzyl bromide and tetranitromethane, both in the presence of guanidine HCl, caused a large reduction in binding capacity. Guanidine CEA cell adhesion molecule 3 Homo sapiens
7 The tyrosine residues of CEA may be classified into three categories: (i) 3 freely reacting residues, (ii) 7 or 8 moderately buried residues and (iii) 15 unreactive residues. Tyrosine CEA cell adhesion molecule 3 Homo sapiens