Title : Nuclear magnetic resonance titration curves of histidine ring protons. Ribonuclease S-peptide and S-proteins.

Pub. Date : 1976 May 10

PMID : 4455






6 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Although S-protein contains 3 histidine residues, four discrete resonances are observed to titrate. Histidine vitronectin Homo sapiens
2 One of these arises from the equivalent histidine residues of unfolded S-protein. Histidine vitronectin Homo sapiens
3 Two of the resonances of the folded S-protein can be assigned to 2 of the histidine residues, 48 and 105, from the close similarity of their titration curves to those in ribonuclease. Histidine vitronectin Homo sapiens
4 The low pH inflection present in the titration curve assigned to histidine residue 48 in ribonuclease is absent from this curve in S-protein. Histidine vitronectin Homo sapiens
5 The third titrating resonance of native S-protein is assigned to the remaining histidine residue at position 119. Histidine vitronectin Homo sapiens
6 The resonance assigned to histidine 119 is the only one significantly affected on the addition of sodium phosphate to S-protein, indicating that some degree of phosphate binding occurs. Histidine vitronectin Homo sapiens