Title : The reversal by pyridostigmine of neuromuscular block produced by soman.

Pub. Date : 1979 May

PMID : 37297






3 Functional Relationships(s)
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1 Pretreatment with pyridostigmine before exposure of the diaphragm to soman, followed by removal of the anticholinesterase from the organ bath, produced a return of tetanic tension and an increase of 5% in functional AChE activity. Pyridostigmine Bromide acetylcholinesterase Rattus norvegicus
2 The changes in synaptic AChE activity were verified pharmacologically by showing a decrease in the blocking activity of acetylcholine in preparations pretreated with pyridostigmine in comparison to those given soman alone following removal of the anti-cholinesterase. Acetylcholine acetylcholinesterase Rattus norvegicus
3 The changes in synaptic AChE activity were verified pharmacologically by showing a decrease in the blocking activity of acetylcholine in preparations pretreated with pyridostigmine in comparison to those given soman alone following removal of the anti-cholinesterase. Pyridostigmine Bromide acetylcholinesterase Rattus norvegicus