Pub. Date : 2022 Aug 1
PMID : 35584723
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, our objective is to study ethanol-induced activation of TGF-beta1 and associated mechanisms of neuroinflammation and apoptosis. | Ethanol | transforming growth factor, beta 1 | Mus musculus |
| 2 | Our study demonstrated that the activation of TGF-beta1 in ethanol ingestion correlated with the induction of free radical generating enzyme NADPH oxidase (NOX). | Ethanol | transforming growth factor, beta 1 | Mus musculus |
| 3 | Further, using TGF-beta type I receptor (TGF-betaRI) inhibitor SB431542 and TGF-beta antagonist Smad7, we established that the alcohol-induced activation of TGF-beta1 impairs antioxidant signaling pathways and leads to neuroinflammation and apoptosis. | 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide | transforming growth factor, beta 1 | Mus musculus |
| 4 | Further, using TGF-beta type I receptor (TGF-betaRI) inhibitor SB431542 and TGF-beta antagonist Smad7, we established that the alcohol-induced activation of TGF-beta1 impairs antioxidant signaling pathways and leads to neuroinflammation and apoptosis. | Alcohols | transforming growth factor, beta 1 | Mus musculus |