Title : Adipose-Derived Circulating Exosomes Promote Protection of the Pulmonary Endothelial Barrier by Inhibiting EndMT and Oxidative Stress through Down-Regulation of the TGF-β Pathway: A Potential Explanation for the Obesity Paradox in ARDS.

Pub. Date : 2022

PMID : 35571250






2 Functional Relationships(s)
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1 Mechanistically, adipose-derived exosomal miR-122-5p promoted the integrity and function of pulmonary endothelial barrier and alleviated fibrogenesis by suppressing EndMT and oxidative stress through down-regulation of the transforming growth factor beta1 (TGF-beta1)/TGF-beta receptor 1 (TGF-betaR1)/Smad2 pathway in vivo and in vitro. mir-122-5p transforming growth factor, beta 1 Mus musculus
2 Mechanistically, adipose-derived exosomal miR-122-5p promoted the integrity and function of pulmonary endothelial barrier and alleviated fibrogenesis by suppressing EndMT and oxidative stress through down-regulation of the transforming growth factor beta1 (TGF-beta1)/TGF-beta receptor 1 (TGF-betaR1)/Smad2 pathway in vivo and in vitro. mir-122-5p transforming growth factor, beta 1 Mus musculus