Pub. Date : 2022 May 9
PMID : 35563897
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We aimed to demonstrate that TC effects on liver phenotypes are dependent on changes in the alpha-CGRP/CALCRL/cAMP/PKA/ERK1/2/TGF-beta1/VEGF axis. | Taurocholic Acid | transforming growth factor, beta 1 | Mus musculus |
| 2 | We aimed to demonstrate that TC effects on liver phenotypes are dependent on changes in the alpha-CGRP/CALCRL/cAMP/PKA/ERK1/2/TGF-beta1/VEGF axis. | Cyclic AMP | transforming growth factor, beta 1 | Mus musculus |
| 3 | RESULTS: TC feeding increased CALCA expression, biliary damage, and liver inflammation and fibrosis, as well as phenotypes that were associated with enhanced immunoreactivity of the PKA/ERK1/2/TGF-beta1/TGF-betaRI/VEGF axis compared to BAC-fed mice and phenotypes that were reversed in alpha-CGRP-/- mice fed TC coupled with changes in hepatic BA composition. | Taurocholic Acid | transforming growth factor, beta 1 | Mus musculus |
| 4 | CONCLUSION: Modulation of the TC/ alpha-CGRP/CALCRL/PKA/ERK1/2/TGF-beta1/VEGF axis may be important in the management of cholangiopathies characterized by BA accumulation. | Taurocholic Acid | transforming growth factor, beta 1 | Mus musculus |