Pub. Date : 2022 Jun
PMID : 35504143
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pirfenidone mitigates TGF-beta1-mediated fibrosis in an idiopathic inflammatory myositis-associated interstitial lung disease model. | pirfenidone | transforming growth factor, beta 1 | Mus musculus |
| 2 | Pirfenidone attenuated IIM-associated ILD with anti-inflammatory properties evidenced by decreased peribronchial inflammation and TGF-beta1 in bronchoalveolar lavage fluid. | pirfenidone | transforming growth factor, beta 1 | Mus musculus |
| 3 | Likewise, pirfenidone attenuated pulmonary fibrosis by fine-tuning TGF-beta1-mediated epithelial-to-mesenchymal and fibrotic signaling pathways; pro-fibrotic SMAD3, ZEB2 and STAT1 expression and activation were decreased, whereas anti-fibrotic SMAD2 activation was increased. | pirfenidone | transforming growth factor, beta 1 | Mus musculus |
| 4 | This study unravels for the first time that pirfenidone has the potential to fine-tune TGF-beta1 fibrotic signaling in IIM-associated ILD. | pirfenidone | transforming growth factor, beta 1 | Mus musculus |