Pub. Date : 2022 Jun 1
PMID : 35460836
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | TGF-beta1 protects trauma-injured murine cortical neurons by upregulating L-type calcium channel Cav1.2 via the p38 pathway. | Calcium | transforming growth factor, beta 1 | Mus musculus |
| 2 | The expression of Cav1.2, an L-type calcium channel (LTCC) isoform, decreased significantly after trauma injury, and this change was reversed by TGF-beta1. | Calcium | transforming growth factor, beta 1 | Mus musculus |
| 3 | Nimodipine, a classic LTCC blocker, abolished the protective effect of TGF-beta1 on trauma-induced neuronal apoptosis. | Nimodipine | transforming growth factor, beta 1 | Mus musculus |
| 4 | Moreover, TGF-beta1 rescued and enhanced the trauma-suppressed neuro-2a intracellular Ca2+ concentration, while the effect of TGF-beta1 was partially inhibited by nimodipine. | Nimodipine | transforming growth factor, beta 1 | Mus musculus |