Title : Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells.

Pub. Date : 2021 Oct 12

PMID : 34641952






1 Functional Relationships(s)
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1 BACKGROUND: SAMHD1 mediates resistance to anti-cancer nucleoside analogues, including cytarabine, decitabine, and nelarabine that are commonly used for the treatment of leukaemia, through cleavage of their triphosphorylated forms. nelarabine SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 Homo sapiens