Title : Transcriptomic analysis of rat kidney reveals a potential mechanism of sex differences in susceptibility to cisplatin-induced nephrotoxicity.

Pub. Date : 2021 Oct

PMID : 34384867






1 Functional Relationships(s)
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1 In particular, along with testicular damage and low testosterone levels, we also observed a decrease in male-specific (CYP3A2) or male-dominant (CYP2B1 and CYP3A1) CYP isoforms in the livers of rats with hepatotoxicity following cisplatin treatment, which may be associated with an imbalance in male hormone regulation caused by renal and testicular injury. Cisplatin cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus