Title : Induction of cortical cholinergic hypofunction and memory retention deficits through intracortical AF64A infusions.

Pub. Date : 1988 Mar 15

PMID : 3359282






2 Functional Relationships(s)
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1 Adult rats given two infusions of AF64A into the right FP cortex had reduced AChE staining throughout 75% of the ipsilateral FP cortex at 10 days following infusion, thus suggesting an extensive cortical diffusion of the agent; minimal non-specific damage was seen (totalling only 4% of the ipsilateral FP cortex for both infusion sites) and no effects on AChE staining were observed in the striatum or hippocampus. ethylcholine aziridinium acetylcholinesterase Rattus norvegicus
2 Adult rats given two infusions of AF64A into the right FP cortex had reduced AChE staining throughout 75% of the ipsilateral FP cortex at 10 days following infusion, thus suggesting an extensive cortical diffusion of the agent; minimal non-specific damage was seen (totalling only 4% of the ipsilateral FP cortex for both infusion sites) and no effects on AChE staining were observed in the striatum or hippocampus. ethylcholine aziridinium acetylcholinesterase Rattus norvegicus