Pub. Date : 2020 Dec 11
PMID : 33344908
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We report the relaxation of methacholine-constricted airways with nebulized MIDD0301, a positive allosteric gamma-aminobutyric acid type A receptor (GABAAR) modulator. | Methacholine Chloride | gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 | Mus musculus |
| 2 | We report the relaxation of methacholine-constricted airways with nebulized MIDD0301, a positive allosteric gamma-aminobutyric acid type A receptor (GABAAR) modulator. | gamma-Aminobutyric Acid | gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 | Mus musculus |
| 3 | These results further demonstrate that charged imidazodiazepine MIDD0301 can selectively target lung GABAAR without adverse motor, cardiovascular, or respiratory effects and inhaled dosing is effective in reducing bronchoconstriction in allergen and infectious lung inflammation. | imidazodiazepine | gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 | Mus musculus |