Pub. Date : 2020 Nov-Dec
PMID : 33144490
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Based on our in vivo experience with digitoxin as an inhibitor of TNFalpha-driven NFkB signaling for cytokine expression in prostate cancer in rats and in cystic fibrosis in humans, we hypothesize that this drug will also block a virally-activated cytokine storm. | Digitoxin | tumor necrosis factor | Rattus norvegicus |
| 2 | Based on our in vivo experience with digitoxin as an inhibitor of TNFalpha-driven NFkB signaling for cytokine expression in prostate cancer in rats and in cystic fibrosis in humans, we hypothesize that this drug will also block a virally-activated cytokine storm. | Digitoxin | nuclear factor kappa B subunit 1 | Rattus norvegicus |
| 3 | RESULTS: The cardiac glycoside digitoxin significantly and differentially suppressed levels of the cytokines TNFalpha, GRO/KC, MIP2, MCP1, and IFNgamma, in the cotton rat lung in the presence of influenza virus. | Digitoxin | tumor necrosis factor | Rattus norvegicus |
| 4 | RESULTS: The cardiac glycoside digitoxin significantly and differentially suppressed levels of the cytokines TNFalpha, GRO/KC, MIP2, MCP1, and IFNgamma, in the cotton rat lung in the presence of influenza virus. | Digitoxin | C-X-C motif chemokine ligand 1 | Rattus norvegicus |
| 5 | RESULTS: The cardiac glycoside digitoxin significantly and differentially suppressed levels of the cytokines TNFalpha, GRO/KC, MIP2, MCP1, and IFNgamma, in the cotton rat lung in the presence of influenza virus. | Digitoxin | C-X-C motif chemokine ligand 2 | Rattus norvegicus |
| 6 | RESULTS: The cardiac glycoside digitoxin significantly and differentially suppressed levels of the cytokines TNFalpha, GRO/KC, MIP2, MCP1, and IFNgamma, in the cotton rat lung in the presence of influenza virus. | Digitoxin | mast cell protease 1-like 1 | Rattus norvegicus |
| 7 | RESULTS: The cardiac glycoside digitoxin significantly and differentially suppressed levels of the cytokines TNFalpha, GRO/KC, MIP2, MCP1, and IFNgamma, in the cotton rat lung in the presence of influenza virus. | Digitoxin | interferon gamma | Rattus norvegicus |