Title : Classical Drug Digitoxin Inhibits Influenza Cytokine Storm, With Implications for Covid-19 Therapy.

Pub. Date : 2020 Nov-Dec

PMID : 33144490






7 Functional Relationships(s)
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1 Based on our in vivo experience with digitoxin as an inhibitor of TNFalpha-driven NFkB signaling for cytokine expression in prostate cancer in rats and in cystic fibrosis in humans, we hypothesize that this drug will also block a virally-activated cytokine storm. Digitoxin tumor necrosis factor Rattus norvegicus
2 Based on our in vivo experience with digitoxin as an inhibitor of TNFalpha-driven NFkB signaling for cytokine expression in prostate cancer in rats and in cystic fibrosis in humans, we hypothesize that this drug will also block a virally-activated cytokine storm. Digitoxin nuclear factor kappa B subunit 1 Rattus norvegicus
3 RESULTS: The cardiac glycoside digitoxin significantly and differentially suppressed levels of the cytokines TNFalpha, GRO/KC, MIP2, MCP1, and IFNgamma, in the cotton rat lung in the presence of influenza virus. Digitoxin tumor necrosis factor Rattus norvegicus
4 RESULTS: The cardiac glycoside digitoxin significantly and differentially suppressed levels of the cytokines TNFalpha, GRO/KC, MIP2, MCP1, and IFNgamma, in the cotton rat lung in the presence of influenza virus. Digitoxin C-X-C motif chemokine ligand 1 Rattus norvegicus
5 RESULTS: The cardiac glycoside digitoxin significantly and differentially suppressed levels of the cytokines TNFalpha, GRO/KC, MIP2, MCP1, and IFNgamma, in the cotton rat lung in the presence of influenza virus. Digitoxin C-X-C motif chemokine ligand 2 Rattus norvegicus
6 RESULTS: The cardiac glycoside digitoxin significantly and differentially suppressed levels of the cytokines TNFalpha, GRO/KC, MIP2, MCP1, and IFNgamma, in the cotton rat lung in the presence of influenza virus. Digitoxin mast cell protease 1-like 1 Rattus norvegicus
7 RESULTS: The cardiac glycoside digitoxin significantly and differentially suppressed levels of the cytokines TNFalpha, GRO/KC, MIP2, MCP1, and IFNgamma, in the cotton rat lung in the presence of influenza virus. Digitoxin interferon gamma Rattus norvegicus