Title : ALG13 participates in epileptogenesis via regulation of GABAA receptors in mouse models.

Pub. Date : 2020

PMID : 33014431






2 Functional Relationships(s)
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1 Whole-cell patch-clamp recordings demonstrated that ALG13KO mice show a marked decrease in gamma-aminobutyric acid A receptor (GABAAR)-mediated inhibitory synaptic transmission. gamma-aminobutyric acid a gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus
2 Furthermore, treatment with low-dose diazepam (a positive allosteric modulator of GABAA receptors), which enhances GABAAR function, also markedly ameliorates severity of epileptic seizures in ALG13KO mice. Diazepam gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus