Title : Early events in murine erythroleukemia cells induced to differentiate. Accumulation and gene expression of the transformation-associated cellular protein p53.

Pub. Date : 1988 Mar 5

PMID : 3288760






2 Functional Relationships(s)
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1 We have investigated the variation in, and the control level of, the accumulation of the transformation-associated cellular protein p53 in murine erythroleukemia cells induced to differentiate by hexamethylene bisacetamide. hexamethylene bisacetamide transformation related protein 53, pseudogene Mus musculus
2 Looking for the regulation mechanism of the p53 decay, we found that the mRNA started to decrease as early as half an hour after the hexamethylene bisacetamide was put in the culture medium, and that the transcription rate of the gene itself could not account for the observed down-regulation of the mRNA, suggesting a post-transcriptional control for the mRNA accumulation. hexamethylene bisacetamide transformation related protein 53, pseudogene Mus musculus