Title : Repurposing Low-Molecular-Weight Drugs against the Main Protease of Severe Acute Respiratory Syndrome Coronavirus 2.

Pub. Date : 2020 Sep 3

PMID : 32787337






2 Functional Relationships(s)
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1 Herein, using ligand- and protein-observed fragment screening approaches, we identified niacin and hit 1 binding to the catalytic pocket of the main protease (Mpro) of SARS-CoV-2, thereby modestly inhibiting the enzymatic activity of Mpro. Niacin NEWENTRY Severe acute respiratory syndrome-related coronavirus
2 Herein, using ligand- and protein-observed fragment screening approaches, we identified niacin and hit 1 binding to the catalytic pocket of the main protease (Mpro) of SARS-CoV-2, thereby modestly inhibiting the enzymatic activity of Mpro. Niacin NEWENTRY Severe acute respiratory syndrome-related coronavirus