Title : Combined inhibition of ACK1 and AKT shows potential toward targeted therapy against KRAS-mutant non-small-cell lung cancer.

Pub. Date : 2021 Apr 1

PMID : 32530390






1 Functional Relationships(s)
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1 The cells were treated with an inhibitor of either ACK1 (dasatinib or sunitinib) or AKT (MK-2206 or GDC-0068), and the optimal concentrations of the two yielding synergistic tumor-killing effects were determined by applying the Chou-Talalay equation for drug combinations. ipatasertib AKT serine/threonine kinase 1 Homo sapiens