Title : Structural Similarity of SARS-CoV2 Mpro and HCV NS3/4A Proteases Suggests New Approaches for Identifying Existing Drugs Useful as COVID-19 Therapeutics.

Pub. Date : 2020 Apr 21

PMID : 32511291






2 Functional Relationships(s)
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1 AutoDock docking scores for 12 HCV protease inhibitors and 9 HIV-1 protease inhibitors were determined and compared to the docking scores for an alpha-ketoamide inhibitor of Mpro, which has recently been shown to inhibit SARS-CoV2 virus replication in cell culture. alpha-ketoamide NEWENTRY Severe acute respiratory syndrome-related coronavirus
2 We identified eight HCV protease inhibitors that bound to the Mpro active site with higher docking scores than the alpha-ketoamide inhibitor, suggesting that these protease inhibitors may effectively bind to the Mpro active site. alpha-ketoamide NEWENTRY Severe acute respiratory syndrome-related coronavirus