Pub. Date : 2020
PMID : 32399094
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The number of hydrogen bonds between statins and amino acid residues of Mpro were 7, 4, and 3 for rosuvastatin, pravastatin, and atorvastatin, respectively, while other statins had two hydrogen bonds. | Hydrogen | NEWENTRY | Severe acute respiratory syndrome-related coronavirus |
| 2 | The number of hydrogen bonds between statins and amino acid residues of Mpro were 7, 4, and 3 for rosuvastatin, pravastatin, and atorvastatin, respectively, while other statins had two hydrogen bonds. | Rosuvastatin Calcium | NEWENTRY | Severe acute respiratory syndrome-related coronavirus |
| 3 | The number of hydrogen bonds between statins and amino acid residues of Mpro were 7, 4, and 3 for rosuvastatin, pravastatin, and atorvastatin, respectively, while other statins had two hydrogen bonds. | Pravastatin | NEWENTRY | Severe acute respiratory syndrome-related coronavirus |
| 4 | The number of hydrogen bonds between statins and amino acid residues of Mpro were 7, 4, and 3 for rosuvastatin, pravastatin, and atorvastatin, respectively, while other statins had two hydrogen bonds. | Atorvastatin | NEWENTRY | Severe acute respiratory syndrome-related coronavirus |
| 5 | The number of hydrogen bonds between statins and amino acid residues of Mpro were 7, 4, and 3 for rosuvastatin, pravastatin, and atorvastatin, respectively, while other statins had two hydrogen bonds. | Hydrogen | NEWENTRY | Severe acute respiratory syndrome-related coronavirus |
| 6 | Conclusions: These results indicate, based upon the binding energy of pitavastatin, rosuvastatin, lovastatin, and fluvastatin, that statins could be efficient SARS-CoV-2 Mpro inhibitors. | Lovastatin | NEWENTRY | Severe acute respiratory syndrome-related coronavirus |