Pub. Date : 2020
PMID : 32339204
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Decorin inhibits glucose-induced lens epithelial cell apoptosis via suppressing p22phox-p38 MAPK signaling pathway. | Glucose | cytochrome b-245 alpha chain | Homo sapiens |
| 2 | P22phox and phospho-p38 MAPK were upregulated in high glucose treated HLEB3 cells. | Glucose | cytochrome b-245 alpha chain | Homo sapiens |
| 3 | Knocking down p22phox or p38 by siRNAs can reduce high glucose induced cell apoptosis and oxidative stress level. | Glucose | cytochrome b-245 alpha chain | Homo sapiens |
| 4 | Decorin can inhibit the apoptosis, oxidative stress level and the induction of p22phox and phospho-p38 of HLEB3 induced by high glucose. | Glucose | cytochrome b-245 alpha chain | Homo sapiens |
| 5 | CONCLUSIONS: Results showed that p22phox-p38 pathway may be participated in high glucose induced lens epithelial cell injury, decorin may inhibit the high glucose induced apoptosis and oxidative stress injury by suppressing this pathway in part. | Glucose | cytochrome b-245 alpha chain | Homo sapiens |