Title : Size changeable nanosystems for precise drug controlled release and efficient overcoming of cancer multidrug resistance.

Pub. Date : 2017 Feb 7

PMID : 32263872






3 Functional Relationships(s)
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1 This PCP/uPA nanosystem was formed through the crosslinking between chitosan (CS) and poly(N-isopropylacrylamide) (PNIPAM), followed by surface decoration with polyethylene glycol (mPEG) and a breast cancer targeting peptide uPA, which was then used to encapsulate metal complexes (RuPOP and Fe(PiP)3) to solve their bottleneck of low solubility and stability under physiological conditions. pip plasminogen activator, urokinase Homo sapiens
2 These multifunctional nanosystems (PCP-Ru/uPA and PCP-Fe/uPA) exhibited remarkable anticancer activity and could overcome the poor stability and low solubility of RuPOP and Fe(PiP)3. pip plasminogen activator, urokinase Homo sapiens
3 These multifunctional nanosystems (PCP-Ru/uPA and PCP-Fe/uPA) exhibited remarkable anticancer activity and could overcome the poor stability and low solubility of RuPOP and Fe(PiP)3. pip plasminogen activator, urokinase Homo sapiens