Pub. Date : 2020 Feb 7
PMID : 32046081
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Several patents have claimed the use of a wide range of pyrazine derivatives as GPR6 inverse agonists for the treatment of Parkinson"s disease symptoms and other dyskinesia syndromes. | Pyrazines | G protein-coupled receptor 6 | Homo sapiens |
| 2 | A subset of patented pyrazine analogs were docked in the resultant GPR6 inactive state model to validate the model, rationalize the structure-activity relationships from the reported patents and identify the key residues in the binding crevice for ligand recognition. | Pyrazines | G protein-coupled receptor 6 | Homo sapiens |