Pub. Date : 2020 Apr
PMID : 32037484
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Estradiol-Induced MMP-9 Expression via PELP1-Mediated Membrane-Initiated Signaling in ERalpha-Positive Breast Cancer Cells. | Estradiol | proline, glutamate and leucine rich protein 1 | Homo sapiens |
| 2 | Proline-, glutamic acid-, leucine-rich protein 1 (PELP1) is a novel estrogen receptor (ER) coregulator, demonstrated distinctive characters from other ERalpha coregulators, and has been suggested to be involved in metastasis of several cancers. | Proline | proline, glutamate and leucine rich protein 1 | Homo sapiens |
| 3 | Proline-, glutamic acid-, leucine-rich protein 1 (PELP1) is a novel estrogen receptor (ER) coregulator, demonstrated distinctive characters from other ERalpha coregulators, and has been suggested to be involved in metastasis of several cancers. | Glutamic Acid | proline, glutamate and leucine rich protein 1 | Homo sapiens |
| 4 | Proline-, glutamic acid-, leucine-rich protein 1 (PELP1) is a novel estrogen receptor (ER) coregulator, demonstrated distinctive characters from other ERalpha coregulators, and has been suggested to be involved in metastasis of several cancers. | Leucine | proline, glutamate and leucine rich protein 1 | Homo sapiens |
| 5 | In ERalpha-positive breast cancer, PELP1 overexpression enhanced ruffles and filopodium-like structure stimulated by estradiol (E2) through extranuclear cell signaling transduction hereby increased cell motility. | Estradiol | proline, glutamate and leucine rich protein 1 | Homo sapiens |
| 6 | In ERalpha-positive breast cancer, PELP1 overexpression enhanced ruffles and filopodium-like structure stimulated by estradiol (E2) through extranuclear cell signaling transduction hereby increased cell motility. | Estradiol | proline, glutamate and leucine rich protein 1 | Homo sapiens |
| 7 | In this study, we investigated the role of PELP1 in E2-induced MMP-9 expression and the underlined mechanism. | Estradiol | proline, glutamate and leucine rich protein 1 | Homo sapiens |
| 8 | Knocked down PELP1 significantly suppressed E2-induced MMP-9 expression. | Estradiol | proline, glutamate and leucine rich protein 1 | Homo sapiens |
| 9 | E2-bovine serum albumin (BSA), a large molecular membrane-impenetrable conjugate of E2, can also upregulate MMP-9 protein expression in MCF-7, and the action of E2-BSA can be abolished by PI3K inhibitor LY294002; treating MCF-7 simultaneously with PELP1-shRNA and LY294002 did not show synergetic inhibitory effect on E2-BSA-induced MMP-9 expression. | Estradiol | proline, glutamate and leucine rich protein 1 | Homo sapiens |