Title : Molecular imaging of oxidative stress using an LED-based photoacoustic imaging system.

Pub. Date : 2019 Aug 6

PMID : 31388020






8 Functional Relationships(s)
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1 Here, we report molecular imaging reactive oxygen and nitrogen species (RONS) with a near-infrared (NIR) absorbing small molecule (CyBA) and LED-based photoacoustic imaging equipment. reactive oxygen and nitrogen species cytochrome b-245 alpha chain Homo sapiens
2 Here, we report molecular imaging reactive oxygen and nitrogen species (RONS) with a near-infrared (NIR) absorbing small molecule (CyBA) and LED-based photoacoustic imaging equipment. rons cytochrome b-245 alpha chain Homo sapiens
3 CyBA produces increasing photoacoustic signal in response to peroxynitrite (ONOO-) and hydrogen peroxide (H2O2) with photoacoustic signal increases of 3.54 and 4.23-fold at 50 microM of RONS at 700 nm, respectively. Peroxynitrous Acid cytochrome b-245 alpha chain Homo sapiens
4 CyBA produces increasing photoacoustic signal in response to peroxynitrite (ONOO-) and hydrogen peroxide (H2O2) with photoacoustic signal increases of 3.54 and 4.23-fold at 50 microM of RONS at 700 nm, respectively. oxido nitrite cytochrome b-245 alpha chain Homo sapiens
5 CyBA produces increasing photoacoustic signal in response to peroxynitrite (ONOO-) and hydrogen peroxide (H2O2) with photoacoustic signal increases of 3.54 and 4.23-fold at 50 microM of RONS at 700 nm, respectively. Hydrogen Peroxide cytochrome b-245 alpha chain Homo sapiens
6 CyBA produces increasing photoacoustic signal in response to peroxynitrite (ONOO-) and hydrogen peroxide (H2O2) with photoacoustic signal increases of 3.54 and 4.23-fold at 50 microM of RONS at 700 nm, respectively. Hydrogen Peroxide cytochrome b-245 alpha chain Homo sapiens
7 CyBA is insensitive to OCl-, NO, NO2-, NO3-, tBuOOH, O2-, C4H9O , HNO, and OH, but can detect ONOO- in whole blood and plasma. onoo cytochrome b-245 alpha chain Homo sapiens
8 CyBA was then used to detect endogenous RONS in macrophage RAW 246.7 cells as well as a rodent model; these results were confirmed with fluorescence microscopy. rons cytochrome b-245 alpha chain Homo sapiens