Pub. Date : 2019 May
PMID : 31005035
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The anti-angiogenic effect of tryptanthrin is mediated by the inhibition of apelin promoter activity and shortened mRNA half-life in human vascular endothelial cells. | tryptanthrine | apelin | Homo sapiens |
| 2 | PURPOSE: We aim to find out if tryptanthrin works on the apelin pathway and study its anti-angiogenic mechanism. | tryptanthrine | apelin | Homo sapiens |
| 3 | METHODS: The effect of tryptanthrin on the expression of apelin and its receptor, APJ, was examined. | tryptanthrine | apelin | Homo sapiens |
| 4 | METHODS: The effect of tryptanthrin on the expression of apelin and its receptor, APJ, was examined. | tryptanthrine | apelin receptor | Homo sapiens |
| 5 | Migration and tube formation assay were used to evaluate the relationship between tryptanthrin and apelin. | tryptanthrine | apelin | Homo sapiens |
| 6 | RESULTS: We demonstrated that tryptanthrin could inhibit the expression of apelin, attenuated the stability of apelin mRNA, and significantly inhibited the apelin promoter activity. | tryptanthrine | apelin | Homo sapiens |
| 7 | RESULTS: We demonstrated that tryptanthrin could inhibit the expression of apelin, attenuated the stability of apelin mRNA, and significantly inhibited the apelin promoter activity. | tryptanthrine | apelin | Homo sapiens |
| 8 | RESULTS: We demonstrated that tryptanthrin could inhibit the expression of apelin, attenuated the stability of apelin mRNA, and significantly inhibited the apelin promoter activity. | tryptanthrine | apelin | Homo sapiens |
| 9 | The addition of apelin-13 restored the suppression of tube formation and migration by tryptanthrin. | tryptanthrine | apelin | Homo sapiens |
| 10 | CONCLUSION: The anti-angiogenic effect of tryptanthrin was mediated by down-regulating apelin gene expression through suppression of promoter activity and decrease of mRNA stability in human vascular endothelial cells. | tryptanthrine | apelin | Homo sapiens |