Title : In vitro sensitivity of normal and hereditary retinoblastoma fibroblasts to DNA-damaging agents.

Pub. Date : 1986 Dec

PMID : 3096561






2 Functional Relationships(s)
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1 Similarly, exposure to actinomycin D led to D0 values of 0.024-0.069 microgram/ml in the nine normal strains and D0 values of 0.016-0.067 microgram/ml in the RB strains (P = 0.64). Dactinomycin RB transcriptional corepressor 1 Homo sapiens
2 The nine RB strains did exhibit a small overall increase in sensitivity after exposure to mitomycin C, with D0 values ranging from 0.14-0.32 microgram/ml versus 0.19-0.66 microgram/ml in the nine normal strains (P = 0.002); however, when the two most resistant normal strains were excluded from analysis, results were similar. Mitomycin RB transcriptional corepressor 1 Homo sapiens