Pub. Date : 1986 Sep 1
PMID : 3091036
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Aldose reductase inhibitors (A.R.I.s), developed as potentially therapeutic agents for the treatment of complications of long-term diabetes, were found to be potent inhibitors of aldose reductase (ALR2) partially purified from bovine retina (IC50 values: Statil 0.89 microM, Sorbinil 2 microM, M79175 greater than 1 microM). | ponalrestat | lens aldose reductase pseudogene | Bos taurus |
| 2 | Aldose reductase inhibitors (A.R.I.s), developed as potentially therapeutic agents for the treatment of complications of long-term diabetes, were found to be potent inhibitors of aldose reductase (ALR2) partially purified from bovine retina (IC50 values: Statil 0.89 microM, Sorbinil 2 microM, M79175 greater than 1 microM). | sorbinil | lens aldose reductase pseudogene | Bos taurus |
| 3 | Statil and Sorbinil were active against ALR2 at very low concentrations (approx. | sorbinil | lens aldose reductase pseudogene | Bos taurus |
| 4 | Valproate, a compound of value in the treatment of epilepsies, was a poor inhibitor of ALR2 (18% at 1 mM). | Valproic Acid | lens aldose reductase pseudogene | Bos taurus |