Title : Identification of the minimal region of peptide derived from ADP-ribosylation factor1 (ARF1) that inhibits IgE-mediated mast cell activation.

Pub. Date : 2019 Jan

PMID : 30472514






2 Functional Relationships(s)
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1 Aggregation of the high affinity IgE receptor (FcepsilonRI) eventually leads to the release of granule components such as histamine, as well as the de novo synthesis of inflammatory cytokines and lipid mediators. Histamine Fc epsilon receptor Ia Homo sapiens
2 Here we show that amino acid residues K10-K16 are necessary for ARF1 peptide to efficiently inhibit FcepsilonRI-induced activation of bone marrow-derived mast cells (BMMCs), indicated by decreased mast cell degranulation, cytokine secretion and leukotriene release. Leukotrienes Fc epsilon receptor Ia Homo sapiens