Pub. Date : 2018 Aug
PMID : 30008927
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Kadsurenone is a useful and promising treatment strategy for breast cancer bone metastases by blocking the PAF/PTAFR signaling pathway. | kadsurenone | platelet activating factor receptor | Homo sapiens |
| 2 | Platelet-activating factor (PAF) is a potent phospholipid mediator, which has previously reported biological activities in BC progression and osteoclast differentiation by activating its receptor PAF receptor (PTAFR). | Phospholipids | platelet activating factor receptor | Homo sapiens |
| 3 | It was further demonstrated that the natural PAF antagonist Kadsurenone may effectively attenuate each process by partially blocking the PAF/PTAFR signaling pathway. | kadsurenone | platelet activating factor receptor | Homo sapiens |
| 4 | Therefore, targeting PAF/PTAFR by Kadsurenone may be a promising treatment strategy for BC bone metastases. | kadsurenone | platelet activating factor receptor | Homo sapiens |