Title : Stimulation of glucose uptake by transforming growth factor beta: evidence for the requirement of epidermal growth factor-receptor activation.

Pub. Date : 1985 Mar

PMID : 2983339






4 Functional Relationships(s)
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1 TGF-beta-induced stimulation of sugar uptake is enhanced by the co-addition of platelet-derived growth factor (10 ng/ml) or epidermal growth factor (EGF, 1 ng/ml). Sugars transforming growth factor, beta 1 Mus musculus
2 Antisera to EGF receptors that block 125I-labeled EGF binding also inhibit TGF-beta stimulation of 2-deoxyglucose uptake, although 125I-labeled TGF-beta binding remains unimpaired. Deoxyglucose transforming growth factor, beta 1 Mus musculus
3 We confirm that the receptor for TGF-beta is distinct from the receptor for EGF and we conclude that TGF-beta stimulation of 2-deoxyglucose uptake requires the co-activation of the EGF receptor kinase system. Deoxyglucose transforming growth factor, beta 1 Mus musculus
4 We confirm that the receptor for TGF-beta is distinct from the receptor for EGF and we conclude that TGF-beta stimulation of 2-deoxyglucose uptake requires the co-activation of the EGF receptor kinase system. Deoxyglucose transforming growth factor, beta 1 Mus musculus