Title : Zoledronate modulates intracellular vesicle trafficking in mast cells via disturbing the interaction of myosinVa/Rab3a and sytaxin4/VAMP7.

Pub. Date : 2018 May

PMID : 29454616






3 Functional Relationships(s)
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1 The present study was undertaken to elucidate the possible effects of zoledronate on FcepsilonRI-dependent mast cell activity in vitro, which is essential for in maintaining homeostasis of the gastrointestinal mucosa. Zoledronic Acid Fc epsilon receptor Ia Homo sapiens
2 Treatment with zoledronate significantly diminished exocytosis of mast cells, which was reflected by a decrease of FcepsilonRI-dependent histamine release compared to that in vehicle-treated mast cells. Zoledronic Acid Fc epsilon receptor Ia Homo sapiens
3 Treatment with zoledronate significantly diminished exocytosis of mast cells, which was reflected by a decrease of FcepsilonRI-dependent histamine release compared to that in vehicle-treated mast cells. Histamine Fc epsilon receptor Ia Homo sapiens