Pub. Date : 2018 May
PMID : 29410184
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interleukin-6 potentiates FcepsilonRI-induced PGD2 biosynthesis and induces VEGF from human in situ-matured skin mast cells. | Prostaglandin D2 | Fc epsilon receptor Ia | Homo sapiens |
| 2 | RESULTS: IL-6 significantly potentiated FcepsilonRI-induced PGD2 biosynthesis, but had no effect on degranulation. | Prostaglandin D2 | Fc epsilon receptor Ia | Homo sapiens |
| 3 | Mechanistically, IL-6 enhanced FcepsilonRI-induced COX-2 expression, PGD2 biosynthesis, and VEGF production in a STAT3 dependent manner. | Prostaglandin D2 | Fc epsilon receptor Ia | Homo sapiens |
| 4 | CONCLUSION: Here, we demonstrate that IL-6 is a potentiator of FcepsilonRI-induced PGD2 biosynthesis, and can induce or enhance production of pro-angiogenesis factors VEGF and IL-8 from human in situ-matured skin mast cells. | Prostaglandin D2 | Fc epsilon receptor Ia | Homo sapiens |