Title : Identification of adenylyl cyclase isoforms mediating parathyroid hormone- and calcitonin-stimulated cyclic AMP accumulation in distal tubule cells.

Pub. Date : 2017 Sep 7

PMID : 28882112






4 Functional Relationships(s)
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1 Individual siRNA knockdown of AC6 and AC9 reduced calcitonin-stimulated cAMP accumulation in 209 cells and PTH-induced cAMP levels in D1 cells. Cyclic AMP adenylate cyclase 6 Mus musculus
2 Individual siRNA knockdown of AC6 and AC9 reduced calcitonin-stimulated cAMP accumulation in 209 cells and PTH-induced cAMP levels in D1 cells. Cyclic AMP adenylate cyclase 6 Mus musculus
3 CONCLUSIONS: Taken together, these findings indicate that AC6 and AC9 mediate calcitonin- and PTH-stimulated cAMP accumulation in DCT cells, while activation of AC7 may paradoxically reduce the stimulatory effects of PTH and calcitonin on cultured DCT cAMP levels. Cyclic AMP adenylate cyclase 6 Mus musculus
4 CONCLUSIONS: Taken together, these findings indicate that AC6 and AC9 mediate calcitonin- and PTH-stimulated cAMP accumulation in DCT cells, while activation of AC7 may paradoxically reduce the stimulatory effects of PTH and calcitonin on cultured DCT cAMP levels. Cyclic AMP adenylate cyclase 6 Mus musculus