Pub. Date : 2017 Nov 7
PMID : 28855374
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Signaling is dependent on recruitment of Syk via docking of its dual SH2 domains to phosphorylated tyrosines within the FcepsilonRI immunoreceptor tyrosine-based activation motifs. | Tyrosine | Fc epsilon receptor Ia | Homo sapiens |
| 2 | Signaling is dependent on recruitment of Syk via docking of its dual SH2 domains to phosphorylated tyrosines within the FcepsilonRI immunoreceptor tyrosine-based activation motifs. | Tyrosine | Fc epsilon receptor Ia | Homo sapiens |
| 3 | Substitution of glutamic acid for tyrosine between the Syk SH2 domains (Syk-Y130E) led to an increased Syk-FcepsilonRI off-rate, loss of site-specific Syk autophosphorylation, and impaired downstream signaling. | Glutamic Acid | Fc epsilon receptor Ia | Homo sapiens |
| 4 | Substitution of glutamic acid for tyrosine between the Syk SH2 domains (Syk-Y130E) led to an increased Syk-FcepsilonRI off-rate, loss of site-specific Syk autophosphorylation, and impaired downstream signaling. | Tyrosine | Fc epsilon receptor Ia | Homo sapiens |