Title : Ginkgolide B Suppresses TLR4-Mediated Inflammatory Response by Inhibiting the Phosphorylation of JAK2/STAT3 and p38 MAPK in High Glucose-Treated HUVECs.

Pub. Date : 2017

PMID : 28785380






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 AIM: Ginkgolide B is a Ginkgo biloba leaf extract that has been identified as a natural platelet-activating factor receptor (PAFR) antagonist. ginkgolide B platelet activating factor receptor Homo sapiens
2 The result showed that high glucose treatment caused the binding of PAFR and TLR4, whereas ginkgolide B abolished this binding. Glucose platelet activating factor receptor Homo sapiens
3 The functional analysis indicated that PAFR siRNA treatment reduced TLR4 expression, and TLR4 siRNA treatment decreased PAFR expression in high glucose-treated HUVECs, further supporting the coimmunoprecipitation data. Glucose platelet activating factor receptor Homo sapiens