Pub. Date : 2017
PMID : 28767701
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVES: Increased expression of adenylyl cyclase type 6 (AC6) has beneficial effects on the heart through cyclic adenosine monophosphate (cAMP)-dependent and cAMP-independent pathways. | Cyclic AMP | adenylate cyclase 6 | Mus musculus |
| 2 | OBJECTIVES: Increased expression of adenylyl cyclase type 6 (AC6) has beneficial effects on the heart through cyclic adenosine monophosphate (cAMP)-dependent and cAMP-independent pathways. | Cyclic AMP | adenylate cyclase 6 | Mus musculus |
| 3 | OBJECTIVES: Increased expression of adenylyl cyclase type 6 (AC6) has beneficial effects on the heart through cyclic adenosine monophosphate (cAMP)-dependent and cAMP-independent pathways. | Cyclic AMP | adenylate cyclase 6 | Mus musculus |
| 4 | We previously generated a catalytically inactive mutant of AC6 (AC6mut) that has an attenuated response to beta-adrenergic receptor stimulation, and, consequently, exhibits reduced myocardial cAMP generation. | Cyclic AMP | adenylate cyclase 6 | Mus musculus |
| 5 | We previously generated a catalytically inactive mutant of AC6 (AC6mut) that has an attenuated response to beta-adrenergic receptor stimulation, and, consequently, exhibits reduced myocardial cAMP generation. | Cyclic AMP | adenylate cyclase 6 | Mus musculus |
| 6 | Isoproterenol infusion caused deleterious effects that were attenuated by cardiac-directed AC6mut expression. | Isoproterenol | adenylate cyclase 6 | Mus musculus |
| 7 | In addition, AC6mut mice showed superior left ventricular function, manifested by higher values for LV peak +dP/dt (p = 0.03), LV peak -dP/dt (p = 0.008), end-systolic pressure-volume relationship (p = 0.003) and cardiac output (p<0.03). | dp | adenylate cyclase 6 | Mus musculus |
| 8 | In addition, AC6mut mice showed superior left ventricular function, manifested by higher values for LV peak +dP/dt (p = 0.03), LV peak -dP/dt (p = 0.008), end-systolic pressure-volume relationship (p = 0.003) and cardiac output (p<0.03). | dp | adenylate cyclase 6 | Mus musculus |
| 9 | In addition, AC6mut mice showed superior left ventricular function, manifested by higher values for LV peak +dP/dt (p = 0.03), LV peak -dP/dt (p = 0.008), end-systolic pressure-volume relationship (p = 0.003) and cardiac output (p<0.03). | Thymidine | adenylate cyclase 6 | Mus musculus |
| 10 | CONCLUSION: Mice with cardiac-directed AC6mut expression weathered the deleterious effects of continuous isoproterenol infusion better than control mice, indicating cardiac protection. | Isoproterenol | adenylate cyclase 6 | Mus musculus |