Pub. Date : 2017 Sep
PMID : 28760822
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Reactivation of Galphai-coupled formyl peptide receptors is inhibited by Galphaq-selective inhibitors when induced by signals generated by the platelet-activating factor receptor. | galphaq | platelet activating factor receptor | Homo sapiens |
| 2 | We show that signals generated by FPRs and the PAF receptor (PAFR) induce activation of the neutrophil O2-, producing NADPH-oxidase, and that response was sensitive to Galphaq inhibition in cells activated by PAF, but no inhibition was obtained in cells activated by FPR agonists. | galphaq | platelet activating factor receptor | Homo sapiens |
| 3 | We show that signals generated by FPRs and the PAF receptor (PAFR) induce activation of the neutrophil O2-, producing NADPH-oxidase, and that response was sensitive to Galphaq inhibition in cells activated by PAF, but no inhibition was obtained in cells activated by FPR agonists. | galphaq | platelet activating factor receptor | Homo sapiens |
| 4 | We show that signals generated by FPRs and the PAF receptor (PAFR) induce activation of the neutrophil O2-, producing NADPH-oxidase, and that response was sensitive to Galphaq inhibition in cells activated by PAF, but no inhibition was obtained in cells activated by FPR agonists. | Platelet Activating Factor | platelet activating factor receptor | Homo sapiens |
| 5 | The downstream sensitivity to Galphaq inhibition in desensitized cells displaying increased production/release of O2- through the PAFR receptor crosstalk mechanism also comprised the reactivation of the FPRs, and the activation signals were redirected from the PAFR to the desensitized/reactivated FPRs. | galphaq | platelet activating factor receptor | Homo sapiens |
| 6 | The downstream sensitivity to Galphaq inhibition in desensitized cells displaying increased production/release of O2- through the PAFR receptor crosstalk mechanism also comprised the reactivation of the FPRs, and the activation signals were redirected from the PAFR to the desensitized/reactivated FPRs. | galphaq | platelet activating factor receptor | Homo sapiens |
| 7 | The downstream sensitivity to Galphaq inhibition in desensitized cells displaying increased production/release of O2- through the PAFR receptor crosstalk mechanism also comprised the reactivation of the FPRs, and the activation signals were redirected from the PAFR to the desensitized/reactivated FPRs. | Superoxides | platelet activating factor receptor | Homo sapiens |
| 8 | The downstream sensitivity to Galphaq inhibition in desensitized cells displaying increased production/release of O2- through the PAFR receptor crosstalk mechanism also comprised the reactivation of the FPRs, and the activation signals were redirected from the PAFR to the desensitized/reactivated FPRs. | Superoxides | platelet activating factor receptor | Homo sapiens |