Title : In vitro metabolism of the new cardiotonic agent denopamine (TA-064) by rat and rabbit liver preparations. Oxidation, methylation, and glucuronidation.

Pub. Date : 1985 Mar-Apr

PMID : 2859176






1 Functional Relationships(s)
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1 3-Methoxydenopamine (M-2) and 3-hydroxy-4-O-methyldenopamine (iso-M-2) were formed via the catechol intermediate M-4, when denopamine was incubated with the rat liver 9000g supernatant fraction in the presence of the NADPH-generating system and S-adenosyl-L-methionine. catechol cholinergic receptor, muscarinic 4 Rattus norvegicus