Title : Hepatic accumulation of pyrophosphate during acetate metabolism.

Pub. Date : 1988 Nov

PMID : 2853160






4 Functional Relationships(s)
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1 However, the further addition of a Ca2+-mobilizing hormone, such as noradrenaline or angiotensin II, together with glucagon to the perfusion medium containing 1 mM acetate caused accumulation of pyrophosphate to a similar level to that observed in vivo. diphosphoric acid carbonic anhydrase 2 Rattus norvegicus
2 However, the further addition of a Ca2+-mobilizing hormone, such as noradrenaline or angiotensin II, together with glucagon to the perfusion medium containing 1 mM acetate caused accumulation of pyrophosphate to a similar level to that observed in vivo. diphosphoric acid angiotensinogen Rattus norvegicus
3 Acetate, glucagon and a Ca2+-mobilizing hormone were all required for accumulation of pyrophosphate in perfused liver. diphosphoric acid carbonic anhydrase 2 Rattus norvegicus
4 These results show that liver cells accumulate a large amount of pyrophosphate during acetate metabolism at high intracellular levels of Ca2+ that can be realized by the synergistic actions of the two kinds of hormones. diphosphoric acid carbonic anhydrase 2 Rattus norvegicus