Title : Continuous physostigmine infusion in rats with excitotoxic lesions of the nucleus basalis magnocellularis: effects on performance in the water maze task and cortical cholinergic markers.

Pub. Date : 1989 Nov

PMID : 2810114






3 Functional Relationships(s)
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1 Acute peripheral administration of physostigmine inhibits cortical acetylcholinesterase (AChE) for about 1 hr in the rat and improves performance on learning and memory paradigms after excitotoxic lesions of the nucleus basalis magnocellularis (NBM) in rats. Physostigmine acetylcholinesterase Rattus norvegicus
2 Acute peripheral administration of physostigmine inhibits cortical acetylcholinesterase (AChE) for about 1 hr in the rat and improves performance on learning and memory paradigms after excitotoxic lesions of the nucleus basalis magnocellularis (NBM) in rats. Physostigmine acetylcholinesterase Rattus norvegicus
3 One week of continuous physostigmine infusion in normal animals inhibited cortical AChE activity in a dose-dependent manner. Physostigmine acetylcholinesterase Rattus norvegicus