Title : Exon skipping of FcεRIβ eliminates expression of the high-affinity IgE receptor in mast cells with therapeutic potential for allergy.

Pub. Date : 2016 Dec 6

PMID : 27872312






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1 Here, we describe an innovative approach for targeting mast cells in vitro and in vivo using antisense oligonucleotide-mediated exon skipping of the beta-subunit of the high-affinity IgE receptor (FcepsilonRIbeta) to eliminate surface high-affinity IgE receptor (FcepsilonRI) expression and function, rendering mast cells unresponsive to IgE-mediated activation. Oligonucleotides Fc epsilon receptor Ia Homo sapiens