Title : The effect of recombinant human granulocyte-macrophage colony-stimulating factor (rGM-CSF) on 3'-azido-3'-deoxythymidine (AZT)-mediated biochemical and cytotoxic effects on normal human myeloid progenitor cells.

Pub. Date : 1989 Jan

PMID : 2783247






3 Functional Relationships(s)
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1 Exposure of nonadherent, bone marrow mononuclear cells (BMMC) to 100 ng/ml of rGM-CSF for 6 h resulted in approximately twofold increments in the mean intracellular deoxycytidine triphosphate (dCTP) and thymidine triphosphate (dTTP) levels. 2'-deoxycytidine 5'-triphosphate colony stimulating factor 2 Rattus norvegicus
2 Exposure of nonadherent, bone marrow mononuclear cells (BMMC) to 100 ng/ml of rGM-CSF for 6 h resulted in approximately twofold increments in the mean intracellular deoxycytidine triphosphate (dCTP) and thymidine triphosphate (dTTP) levels. 2'-deoxycytidine 5'-triphosphate colony stimulating factor 2 Rattus norvegicus
3 Coadministration of rGM-CSF (100 ng/ml) along with AZT (10 microM) partly restored dCTP and dTTP levels and significantly reduced AZT-TP levels. 2'-deoxycytidine 5'-triphosphate colony stimulating factor 2 Rattus norvegicus