Pub. Date : 1989 Aug
PMID : 2760844
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Release was monitored by measuring endogenous ACh when acetylcholinesterase (AChE) was inhibited with physostigmine (30 microM) or by measuring endogenous choline when AChE activity was left intact. | Acetylcholine | acetylcholinesterase | Rattus norvegicus |
| 2 | Release was monitored by measuring endogenous ACh when acetylcholinesterase (AChE) was inhibited with physostigmine (30 microM) or by measuring endogenous choline when AChE activity was left intact. | Physostigmine | acetylcholinesterase | Rattus norvegicus |
| 3 | Release was monitored by measuring endogenous ACh when acetylcholinesterase (AChE) was inhibited with physostigmine (30 microM) or by measuring endogenous choline when AChE activity was left intact. | Physostigmine | acetylcholinesterase | Rattus norvegicus |
| 4 | Release was monitored by measuring endogenous ACh when acetylcholinesterase (AChE) was inhibited with physostigmine (30 microM) or by measuring endogenous choline when AChE activity was left intact. | Choline | acetylcholinesterase | Rattus norvegicus |
| 5 | The classical antagonist, atropine (0.1-2 microM), induced an increase in release whether AChE activity was inhibited or intact. | Atropine | acetylcholinesterase | Rattus norvegicus |
| 6 | The putative M-1 selective antagonist, pirenzepine, had minimal effects over a broad concentration range (2-200 microM) and induced an increase in ACh release only when AChE activity was inhibited. | Pirenzepine | acetylcholinesterase | Rattus norvegicus |
| 7 | The classical agonist, oxotremorine (10-100 microM) decreased effectively ACh release (by 22-35%), but only when AChE activity was intact. | Oxotremorine | acetylcholinesterase | Rattus norvegicus |
| 8 | The oxotremorine analog, oxotremorine-M, was apparently more potent than oxotremorine, but also decreased ACh release (by 24-41%) only when AChE activity was intact. | Oxotremorine | acetylcholinesterase | Rattus norvegicus |
| 9 | The oxotremorine analog, oxotremorine-M, was apparently more potent than oxotremorine, but also decreased ACh release (by 24-41%) only when AChE activity was intact. | Oxotremorine | acetylcholinesterase | Rattus norvegicus |
| 10 | The oxotremorine analog, oxotremorine-M, was apparently more potent than oxotremorine, but also decreased ACh release (by 24-41%) only when AChE activity was intact. | Oxotremorine | acetylcholinesterase | Rattus norvegicus |
| 11 | Another oxotremorine analog, BM-5, behaved more like a muscarinic antagonist in its effects on neostriatal ACh release, and the highest concentration tested (100 microM) increased release (by 47%) when AChE activity was left intact. | Oxotremorine | acetylcholinesterase | Rattus norvegicus |
| 12 | Another oxotremorine analog, BM-5, behaved more like a muscarinic antagonist in its effects on neostriatal ACh release, and the highest concentration tested (100 microM) increased release (by 47%) when AChE activity was left intact. | N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide | acetylcholinesterase | Rattus norvegicus |