Pub. Date : 2016 Oct
PMID : 27580186
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Design, synthesis and biological evaluation of dihydroquinoxalinone derivatives as BRD4 inhibitors. | dihydroquinoxalinone | bromodomain containing 4 | Homo sapiens |
| 2 | In this study, we synthesized a series of dihydroquinoxalinone derivatives and evaluated their BRD4 inhibitory activities, obtaining compound 5i with IC50 value of 73nM of binding activity in BRD4(1) and 258nM of cellular activity in MV-4-11 cancer cell lines. | dihydroquinoxalinone | bromodomain containing 4 | Homo sapiens |
| 3 | In this study, we synthesized a series of dihydroquinoxalinone derivatives and evaluated their BRD4 inhibitory activities, obtaining compound 5i with IC50 value of 73nM of binding activity in BRD4(1) and 258nM of cellular activity in MV-4-11 cancer cell lines. | dihydroquinoxalinone | bromodomain containing 4 | Homo sapiens |