Pub. Date : 2017 Aug
PMID : 27494802
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The lysine residues of Bromodomain-1 (BD1) of Brd4 undergo epsilon-N-Acetylation posttranslational modifications to control transcription of genes. | Lysine | bromodomain containing 4 | Homo sapiens |
| 2 | In this study, an attempt has been made to screen compounds from flavonoids and extended flavonoids libraries targeting acetylated lysine (KAc) binding site of BD1 of Brd4 using docking and molecular dynamics simulations. | Flavonoids | bromodomain containing 4 | Homo sapiens |
| 3 | In this study, an attempt has been made to screen compounds from flavonoids and extended flavonoids libraries targeting acetylated lysine (KAc) binding site of BD1 of Brd4 using docking and molecular dynamics simulations. | Flavonoids | bromodomain containing 4 | Homo sapiens |
| 4 | In this study, an attempt has been made to screen compounds from flavonoids and extended flavonoids libraries targeting acetylated lysine (KAc) binding site of BD1 of Brd4 using docking and molecular dynamics simulations. | Lysine | bromodomain containing 4 | Homo sapiens |
| 5 | We have identified a flavonoid which shows docking and Glide e-model score comparatively much higher than those of already reported known inhibitors against Brd4. | Flavonoids | bromodomain containing 4 | Homo sapiens |
| 6 | The protein-ligand complex with top-ranked flavonoid was used for dynamics simulation study for 50 ns in order to validate its stability inside the active site of Brd4 receptor. | Flavonoids | bromodomain containing 4 | Homo sapiens |