Title : NMR-based platform for fragment-based lead discovery used in screening BRD4-targeted compounds.

Pub. Date : 2016 Jul

PMID : 27238211






3 Functional Relationships(s)
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Protein Name
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1 Analysis of the binding interactions revealed that compounds 1 and 2 shared a common quinazolin core structure and bound to BRD4(I) in a non-acetylated lysine mimetic mode. Lysine bromodomain containing 4 Homo sapiens
2 Four potential hit-to-lead optimization candidates have been found, two of them bound to BRD4(I) in a non-acetylated lysine mimetic mode, being selective BRD4(I) inhibitors. Lysine bromodomain containing 4 Homo sapiens
3 Four potential hit-to-lead optimization candidates have been found, two of them bound to BRD4(I) in a non-acetylated lysine mimetic mode, being selective BRD4(I) inhibitors. Lysine bromodomain containing 4 Homo sapiens