Pub. Date : 2016 Jun
PMID : 26659468
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OCT1 mediates hepatic uptake of sumatriptan and loss-of-function OCT1 polymorphisms affect sumatriptan pharmacokinetics. | Sumatriptan | solute carrier family 22 member 1 | Homo sapiens |
| 2 | OCT1 mediates hepatic uptake of sumatriptan and loss-of-function OCT1 polymorphisms affect sumatriptan pharmacokinetics. | Sumatriptan | solute carrier family 22 member 1 | Homo sapiens |
| 3 | OCT1 mediates hepatic uptake of sumatriptan and loss-of-function OCT1 polymorphisms affect sumatriptan pharmacokinetics. | Sumatriptan | solute carrier family 22 member 1 | Homo sapiens |
| 4 | OCT1 transported sumatriptan with high capacity and sumatriptan uptake into human hepatocytes was strongly inhibited by the OCT1 inhibitor MPP(+) . | Sumatriptan | solute carrier family 22 member 1 | Homo sapiens |
| 5 | OCT1 transported sumatriptan with high capacity and sumatriptan uptake into human hepatocytes was strongly inhibited by the OCT1 inhibitor MPP(+) . | Sumatriptan | solute carrier family 22 member 1 | Homo sapiens |
| 6 | In conclusion, OCT1 is a high-capacity transporter of sumatriptan and polymorphisms causing OCT1 deficiency have similar effects on sumatriptan pharmacokinetics as those observed in subjects with liver impairment. | Sumatriptan | solute carrier family 22 member 1 | Homo sapiens |
| 7 | In conclusion, OCT1 is a high-capacity transporter of sumatriptan and polymorphisms causing OCT1 deficiency have similar effects on sumatriptan pharmacokinetics as those observed in subjects with liver impairment. | Sumatriptan | solute carrier family 22 member 1 | Homo sapiens |