Title : Tumor-selective use of DNA base excision repair inhibition in pancreatic cancer using the NQO1 bioactivatable drug, β-lapachone.

Pub. Date : 2015 Nov 25

PMID : 26602448






2 Functional Relationships(s)
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1 Combining ss-lapachone with XRCC1 knockdown or methoxyamine (MeOX), an apyrimidinic/apurinic (AP)-modifying agent, led to NQO1-dependent synergistic killing in PDA, NSCLC, breast and head and neck cancers. methoxyamine NAD(P)H dehydrogenase, quinone 1 Mus musculus
2 Combining ss-lapachone with XRCC1 knockdown or methoxyamine (MeOX), an apyrimidinic/apurinic (AP)-modifying agent, led to NQO1-dependent synergistic killing in PDA, NSCLC, breast and head and neck cancers. methoxyamine NAD(P)H dehydrogenase, quinone 1 Mus musculus