Pub. Date : 2015 Nov 10
PMID : 26497555
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we show that at moderate levels of ROS, Sp1 directly binds to two GC boxes within the ZNF32 promoter to activate ZNF32 transcription. | Reactive Oxygen Species | zinc finger protein 32 | Homo sapiens |
| 2 | Here, we show that at moderate levels of ROS, Sp1 directly binds to two GC boxes within the ZNF32 promoter to activate ZNF32 transcription. | Reactive Oxygen Species | zinc finger protein 32 | Homo sapiens |
| 3 | Alternatively, at cytotoxic ROS concentrations, ZNF32 expression is repressed due to decreased binding activity of Sp1. | Reactive Oxygen Species | zinc finger protein 32 | Homo sapiens |
| 4 | ZNF32 overexpression maintains mitochondrial membrane potential and enhances the antioxidant capacity of cells to detoxify ROS, and these effects promote cell survival upon pro-oxidant agent treatment. | Reactive Oxygen Species | zinc finger protein 32 | Homo sapiens |