Title : Downregulating p22phox ameliorates inflammatory response in Angiotensin II-induced oxidative stress by regulating MAPK and NF-κB pathways in ARPE-19 cells.

Pub. Date : 2015 Sep 29

PMID : 26415877






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Inhibition of p22phox, an indispensable component of the NADPH oxidase (NOX) complex comprising the main source of ROS, plays a protective role in many ocular conditions by inhibiting the activation of NOXs and the generation of ROS. Reactive Oxygen Species cytochrome b-245 alpha chain Homo sapiens
2 Inhibition of p22phox, an indispensable component of the NADPH oxidase (NOX) complex comprising the main source of ROS, plays a protective role in many ocular conditions by inhibiting the activation of NOXs and the generation of ROS. Reactive Oxygen Species cytochrome b-245 alpha chain Homo sapiens
3 Downregulating p22phox resulted in decreased ROS generation, a reduction of NOXs (NOX1, 2, 4) and a decrease in inflammatory cytokine. Reactive Oxygen Species cytochrome b-245 alpha chain Homo sapiens